Molecular tests for hematology and oncology

  • ›Acute Lymphoblastic Leukemia, ALL panel
  • ›Acute Myeloblastic Leukemia, AML panel
  • ›Chronic Myelogenous Leukemia, CML panel
  • ›Minimal Residual Disease (MRD)
  • ›Myeloproliferative Neoplasm (MPN, MPD)

 

 

panel malignancy Hematology
Chronic Myeloproliferative disorders (CML) t(9;22) (BCR-ABL p210)Jak V617F mutation

MPL exon10 mutation detection

FIP1L1-PDGFRa, CHIC2, (4q12)

FIP1L1-PDGFRa,CHIC2,(4q12) Quantitative

t(5;12)(q33;p13)ETV6/PDGFRB

Acute myelogenous leukemia (AML) t(15;17) (PML-RARa)t(8;21)

inv (16)

t(11;17)

11q23/MLL

FLT3 ITD , WT1 Muation analysis, NPM1 mutation

11q rearrangment

t(6;11)(q27;q23) AF6/MLL Qualitative/ Quantitative

11q rearrangment t(9;11)(p22;q23) AF9-MLL Qualitative/ Quantitative

11q rearrangment t(10;11)(p13;q23)AF10/MLL Qualitative/ Quantitative

11q rearrangment t(11;19)(q23;p13.1) MLL/ELL Qualitative/ Quantitative

11q rearrangement , t(11;19)(q23;p13.3) MLL/ENL Qualitative/ Quantitative

inv(3)(q21q26.2) or t(3;3)(q21;q26.2) (RPN1/MECOM) Qualitative

t(6;9)(p23;q34) DEK/NUP214 (formerly DEK/CAN) Qualitative/ Quantitative

MDS Loss of the Y chromosomeLoss of the 3q

Chromosome 5 / 5q deletions

Chromosome 7 / 7q deletions

Chromosome 8 / Chromosome 8 gains

JAK2 mutation, at 9p24.1

Chromosome 11 / 11q deletions and amplifications

Chromosome 12 / Loss of 12p

Chromosome 17 / Loss of 17p and gain of 17q (TP53)

Gain of Chromosome 19

Chromosome 20 / Loss of 20q

Acute Lymphoblastic Leukemia (B- ALL) t (12;21)Qualitative/ Quantitative

t (1;19)

Qualitative/ Quantitative

t (4;11)

Qualitative/ Quantitative

t (9;22) (BCR-ABL p 190 and p 210)

Qualitative/ Quantitative

Acute Lymphoblastic Leukemia (T- ALL) 1p33 deletion ,STIL-TAL1 fusion1p33 deletion ,STIL-TAL1 fusion

Quantitative

4q25 Mono/biallelicmicrodeletions LEF1 gene

6q23.3, Duplication of the MYB oncogene

deletion at 7q36.1, EZH2 gene

9p21.3,CDKN2A/B, MTAP and MLLT3 genes deletion

9q34.12-q13,

NUP214-ABL1 fusion gene

10q23.31 PTEN deletions

11p15.4, LMO1 gene amplification

17q11.2,NF1 and SUZ12 genes deletion

18p11.21, PTPN2 gene deletion

Xq26.2,PHF6 gene deletion

CLL 11q deletion, ATM at 11q22.3.Trisomy 12

13q14 deletion, RB1 gene

17p13.1 deletion TP53 gene

t(14;18)(q32;q21) IGH/BCL2 Qualitative

Multiple Myeloma Deletion of 1p1q amplifications

5q amplifications and gains

Chromosome 9 gains

12p deletions

13q deletions

14q32.32 deletion,TRAF3 gene deletion

Chromosome 15 gains

16q12 and 16q23 deletions

17p13.1 deletion, TP53

t(4;14)(p16;q32) IGH/FGFR3 and

WHSC1

t(11;14)(q13;q32)

IGH/CCND1

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